(HIPPOCAMPUS) DYSFUNCTION & FIBROMYALGIA
Brain Dysfunction May Explain Fibromyalgia
Dysfunction in a portion of the brain may
explain some of the
symptoms of Fibromyalgia syndrome, researchers
suggest in a paper
published in the Journal of Rheumatology Dr. Yasser
Emad, of Cairo
University, Egypt, and colleagues used proton magnetic
spectroscopy to examine the function of the hippocampus in
patients with Fibromyalgia syndrome and in10 healthy women
were the same age as the other patients.
The hippocampus is
located deep in the front portion of the brain
involved in regulating
emotions and memory. Functionally, the
hippocampus is part of the
olfactory cortex, which is important to the
sense of smell. The name is
from the Greek hippos (horse) = kampos
(a sea monster), based on its
shape, which resembles a seahorse.
Using spectroscopy, the researchers
calculated levels of hippocampus
levels of the brain chemicals N-acetyl
aspartate (NAA), choline,
creatine, along with their ratios, and compared
the findings between the
two groups. All study participants also
underwent assessments of sleep
patterns, cognitive function, and symptoms
In the patient group, language scores were significantly
choline and creatine levels, but there was no significant
between the levels of the metabolites or their ratios and the
"The hippocampus was dysfunctional in
patients with Fibromyalgia, as
shown by lower NAA levels," the
Because the hippocampus has a critical role in
functions, sleep regulation, and pain perception,
suggest that metabolic dysfunction of hippocampus may be
in the symptoms of this puzzling syndrome.
of tender points on the body was assessed in all patients
and a visual analog
scale was used to measure pain.
Patient age averaged 35.7 years, and
their average disease duration
was 18.1 months. All of the patients had
impairments on the Mini-Mental State Examination,
eight (35.5 percent)
were depressed according to the Hamilton Depression
and nine (60 percent) had sleep disturbances. None of the
subjects had any problems in these areas.
"NAA levels of the
right and left hippocampi were lower in the
patients compared to controls,"
Emad's team explains. "Another
statistically significant difference was
observed in choline levels in
the right hippocampus, which were higher in the
patient group." The
Fibromyalgia patients also had significantly lower
NAA to choline and
NAA to creatine ratios compared with the control
There were no differences between the groups in other
measured or in the choline to creatine ratio.
patient group, language scores were significantly correlated with
and creatine levels, but there was no significant correlation
levels of the metabolites or their ratios and the number
"The hippocampus was dysfunctional in patients with Fibromyalgia,
shown by lower NAA levels," the investigators conclude.
the hippocampus has a critical role in maintaining cognitive
sleep regulation, and pain perception, the researchers
metabolic dysfunction of hippocampus may be
in the symptoms of this puzzling
This research may
explain why certain therapeutic grade essential oils with specific electrical frequencies) have helped me since
2001. They affect the limbic portion of the
brain via the olfactory system, which is tied to the
hippocampus. I hope researchers will continue this
intriguing investigation into brain function and FMS/CFIDS.
Regular medical tests seem to always come back "normal," yet we know our
bodies are not functioning normally! My husband thinks our "computer"
(brain) has some kind of an electrical malfunction -
maybe due to genetics, stress, viruses, weather, molds, toxins.....who
knows?! Write firstname.lastname@example.org for info about therapeutic essential oils. Also
see www.fms-help.com/oils.htm and www.oil-testimonials.com/6861.
Dominie's 100 Tips for Coping with
Fibromyalgia & Insomnia
My Fibromyalgia Story
My Insomnia Story
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